CAS No. 1185-57-5
| IUPAC Name | azane;2-hydroxypropane-1,2,3-tricarboxylic acid;iron(3+) | |
|---|---|---|
| CAS Number | 1185-57-5 | |
| Molecular Formula |
C24H32Fe3N3O28 |
|
| Molecular Weight (MW) | 978.05 | |
| SMILES | [NH4+].[NH4+].[NH4+].[Fe+3].[Fe+3].[Fe+3].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O | |
| InChIKey | FRHBOQMZUOWXQL-UHFFFAOYSA-N |
Ammonium ferric citrate is an iron salt and ferroptosis inducer that targets the GPX4-GSS/GSR-GGT pathway. Inhibition of this axis suppresses cellular antioxidant defenses and induces oxidative stress injury in non-small-cell lung carcinoma cells. Downstream, this pathway disruption impairs metabolic and biosynthetic processes, inhibits cell proliferation and invasion, and decreases autophagy, ultimately triggering iron-dependent cell death through ferroptosis. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 53 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 53 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Ammonium ferric citrate Solubility in DMSO
- Ammonium ferric citrate Stock Solution
- Ammonium ferric citrate Storage
- Ammonium ferric citrate Stability
- Ammonium ferric citrate Molecular Weight
- Ammonium ferric citrate SMILES
- Ammonium ferric citrate Chemical Structure (2D and 3D)
- Ammonium ferric citrate SDS｜MSDS