CAS No. 1401033-86-0
Batch:
Purity:99.27
Chemical Structure
Check the
AMG 925
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-hydroxy-1-[2-[[8-(4-methylcyclohexyl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethanone | |
|---|---|---|
| CAS Number | 1401033-86-0 | |
| Molecular Formula |
C26H29N7O2 |
|
| Molecular Weight (MW) | 471.55 | |
| SMILES | CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5 | |
| InChIKey | BBUVDDPUURMFOX-UHFFFAOYSA-N |
AMG 925 is an orally bioavailable dual inhibitor targeting FLT3 (IC50 1 nM) and CDK4 (IC50 3 nM). By concurrently suppressing FLT3 and CDK4 signaling pathways, it blocks cell cycle progression at the G1 phase and downregulates downstream survival signaling. This dual mechanism leads to significant inhibition of cellular proliferation and induction of apoptosis in acute myeloid leukemia preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
0.01 mg/mL
(0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.