CAS No. 945595-80-2

Batch: Purity:99.92
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AMG-900 Chemical Structure
Chemical Structure
Check the AMG-900 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-[[3-(2-aminopyrimidin-4-yl)-2-pyridinyl]oxy]phenyl]-4-(4-methylthiophen-2-yl)phthalazin-1-amine
CAS Number 945595-80-2
Molecular Formula

C28H21N7OS
Molecular Weight (MW) 503.58
SMILES CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N
InChIKey IVUGFMLRJOCGAS-UHFFFAOYSA-N

Biological Activity

AMG-900 is a potent, pan-Aurora kinase inhibitor targeting Aurora A (IC50 5 nM), Aurora B, and Aurora C (IC50 1 nM). It inhibits autophosphorylation of Aurora A and B and downregulates histone H3 phosphorylation. Consequently, AMG-900 suppresses cellular proliferation, impairs mitosis without stable mitotic arrest, and induces endoreduplication and cell death across diverse tumor cell lines, including multidrug-resistant models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Payton M, et al. Cancer Res. 2010;70(23):9846-54.

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Note: Technical data last updated: Sep 1, 2026.