CAS No. 882663-88-9
Batch:
Purity:99.10
Chemical Structure
Check the
AMG-47a
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-3-[2-(2-morpholin-4-ylethylamino)quinazolin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide | |
|---|---|---|
| CAS Number | 882663-88-9 | |
| Molecular Formula |
C29H28F3N5O2 |
|
| Molecular Weight (MW) | 535.56 | |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=CN=C(N=C4C=C3)NCCN5CCOCC5 | |
| InChIKey | DVRSTRMZTAPMKO-UHFFFAOYSA-N |
AMG-47a is a small-molecule inhibitor that targets lymphocyte-specific protein tyrosine kinase (Lck). By inhibiting Lck enzymatic activity, AMG-47a disrupts T-cell receptor (TCR) signaling cascades and downstream signaling pathways essential for T-lymphocyte activation. This inhibition effectively attenuates downstream cellular functions, leading to reduced T-cell proliferation and decreased anti-CD3-induced interleukin-2 (IL-2) production, thereby exhibiting robust anti-inflammatory activity in immunodynamics assays. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
2 mg/mL
(3.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.