CAS No. 1883727-34-1

Batch: Purity:98.50
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Tapotoclax (AMG-176) Chemical Structure
Chemical Structure
Check the Tapotoclax (AMG-176) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3'R,4S,6'R,7'S,8'E,11'S,12'R)-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one
CAS Number 1883727-34-1
Molecular Formula

C33H41ClN2O5S
Molecular Weight (MW) 613.21
SMILES CC1CC=CC(C2CCC2CN3CC4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)C1C)OC
InChIKey JQNINBDKGLWYMU-GEAQBIRJSA-N

Ordering Information

Biological Activity

Tapotoclax (AMG-176) is a potent, selective, and orally bioavailable macrocyclic inhibitor of myeloid cell leukemia 1 (MCL1) with a Ki of. By disrupting MCL1 interactions with pro-apoptotic BCL-2 family proteins, AMG-176 promotes mitochondrial outer membrane permeabilization and activates downstream caspase cascades, ultimately inducing rapid and robust apoptosis across various preclinical models of hematologic malignancies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (163.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.