CAS No. 30578-37-1

Batch: Purity:99.86
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Amezinium (methylsulfate) Chemical Structure
Chemical Structure
Check the Amezinium (methylsulfate) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-methoxy-1-phenylpyridazin-1-ium-4-amine;methyl sulfate
CAS Number 30578-37-1
Molecular Formula

C12H15N3O5S
Molecular Weight (MW) 313.33
SMILES COC1=[N+](N=CC(=C1)N)C2=CC=CC=C2.COS(=O)(=O)[O-]
InChIKey ZEASXVYVFFXULL-UHFFFAOYSA-N

Ordering Information

Biological Activity

Amezinium methylsulfate is a sympathomimetic agent that acts as a monoamine oxidase (MAO) inhibitor and blocks the neuronal uptake of noradrenaline while antagonizing tyramine-induced responses. By inhibiting noradrenaline reuptake and enzymatic degradation, it elevates synaptic noradrenaline concentrations, leading to enhanced vascular smooth muscle contraction and increased peripheral vascular resistance, which restores blood pressure in hypotensive states.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (201.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 32 mg/mL
Ethanol 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.