CAS No. 185991-07-5
| CAS Number | 185991-07-5 | |
|---|---|---|
| Molecular Formula |
C24H38N6.6HBr |
|
| Molecular Weight (MW) | 896.07 | |
| SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CNCC3=CC=CC=N3.Br.Br.Br.Br.Br.Br |
AMD3465 is a selective monomacrocyclic antagonist of the chemokine receptor CXCR4. By binding to CXCR4, it effectively blocks interaction with its ligand CXCL12, disrupting downstream receptor activation and intracellular signal transduction pathways. This functional inhibition attenuates CXCL12-induced calcium mobilization, inhibits chemotactic cell migration, and reduces CXCR4-mediated cellular recruitment and proliferation across various cell-based models.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 98 mg/mL |
| DMSO |
2 mg/mL
(2.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- AMD3465 hexahydrobromide Solubility in DMSO
- AMD3465 hexahydrobromide Stock Solution
- AMD3465 hexahydrobromide Storage
- AMD3465 hexahydrobromide Stability
- AMD3465 hexahydrobromide Molecular Weight
- AMD3465 hexahydrobromide SMILES
- AMD3465 hexahydrobromide Chemical Structure (2D and 3D)
- AMD3465 hexahydrobromide SDS｜MSDS