CAS No. 177036-94-1

Batch: Purity:99.98
Check CoA
Ambrisentan Chemical Structure
Chemical Structure
Check the Ambrisentan product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid
CAS Number 177036-94-1
Molecular Formula

C22H22N2O4
Molecular Weight (MW) 378.42
SMILES CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChIKey OUJTZYPIHDYQMC-LJQANCHMSA-N

Ordering Information

Biological Activity

Ambrisentan is a highly selective antagonist of the endothelin-1 type A (ETA) receptor. By blocking endothelin-1 binding to the ETA receptor, it inhibits endothelin-mediated intracellular calcium influx, vasoconstriction, and vascular smooth muscle cell proliferation. This selective pathway inhibition reduces pulmonary vascular resistance and suppresses downstream vascular remodeling, mitigating disease progression in preclinical models of pulmonary arterial hypertension. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.