CAS No. 2446872-46-2

Batch: Purity:99.78
Check CoA
AM-9022 Chemical Structure
Chemical Structure
Check the AM-9022 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[[(2R)-1-hydroxypropan-2-yl]sulfonylamino]benzamide
CAS Number 2446872-46-2
Molecular Formula

C27H36F2N6O4S
InChIKey OLCRYQGHHMGOJZ-LJQANCHMSA-N

Biological Activity

AM-9022 is an orally active, potent, and selective inhibitor of kinesin-like protein 18A (KIF18A), a mitotic kinesin motor protein critical for chromosome alignment and segregation. By targeting KIF18A, AM-9022 disrupts mitotic spindle dynamics and impairs proper chromosome positioning, leading to mitotic arrest and apoptosis. Consequently, this compound demonstrates significant anti-cancer efficacy in human breast and ovarian tumor models. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Mayr MI, et al. Curr Biol. 2007;17(6):488-98.

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Note: Technical data last updated: Sep 1, 2026.