CAS No. 170098-38-1

Batch: Purity:99.05
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Alvimopan dihydrate (LY246736 dihydrate) Chemical Structure
Chemical Structure
Check the Alvimopan dihydrate (LY246736 dihydrate) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid;dihydrate
CAS Number 170098-38-1
Molecular Formula

C25H36N2O6
Molecular Weight (MW) 460.56
SMILES CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O.O.O
InChIKey USPVLEIQIUNQGE-DBFLIVQGSA-N

Ordering Information

Biological Activity

Alvimopan dihydrate (LY246736 dihydrate) is a peripherally acting opioid antagonist targeting the μ-opioid receptor (Ki 0.77 nM), δ-opioid receptor (Ki 4.4 nM), and κ-opioid receptor (Ki 40 nM). It displays over 100-fold selectivity for opioid receptors relative to aminergic G-protein-coupled receptors. By selectively blocking peripheral μ-opioid receptors, alvimopan inhibits opioid-induced gastrointestinal hypomotility without compromising central analgesic signaling pathways. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.