CAS No. 1345847-93-9
Batch:
Purity:99.82
Chemical Structure
Check the
Altiratinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-N'-[4-[[2-(cyclopropanecarbonylamino)-4-pyridinyl]oxy]-2,5-difluorophenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | |
|---|---|---|
| CAS Number | 1345847-93-9 | |
| Molecular Formula |
C26H21F3N4O4 |
|
| Molecular Weight (MW) | 510.46 | |
| SMILES | C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F | |
| InChIKey | GNNDEPIMDAZHRQ-UHFFFAOYSA-N |
Altiratinib is a multi-kinase inhibitor targeting TRKA, TRKB, TRKC, MET, TIE2, and VEGFR2. By blocking these receptor tyrosine kinases, it effectively inhibits MET phosphorylation and downstream RAS/MAPK and PI3K/AKT signaling cascades. Consequently, altiratinib suppresses tumor cell proliferation, migration, invasion, and angiogenesis across diverse preclinical cancer models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.