CAS No. 51411-04-2
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Chemical Structure
Check the
Alrestatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(1,3-dioxobenzo[de]isoquinolin-2-yl)acetic acid | |
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| CAS Number | 51411-04-2 | |
| Molecular Formula |
C14H9NO4 |
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| Molecular Weight (MW) | 255.23 | |
| SMILES | C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CC(=O)O | |
| InChIKey | GCUCIFQCGJIRNT-UHFFFAOYSA-N |
Alrestatin is an aldose reductase inhibitor that targets the polyol pathway involved in diabetic complications. By blocking aldose reductase, alrestatin prevents the NADPH-dependent reduction of glucose to sorbitol, thereby reducing intracellular sorbitol accumulation. This inhibition attenuates osmotic stress and tissue damage, contributing to the mitigation of diabetic neuropathy and related microvascular pathologies. [1]
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.