CAS No. 604-59-1
Batch:
Purity:98.85
Chemical Structure
Check the
alpha-Naphthoflavone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-phenylbenzo[h]chromen-4-one | |
|---|---|---|
| CAS Number | 604-59-1 | |
| Molecular Formula |
C19H12O2 |
|
| Molecular Weight (MW) | 272.30 | |
| SMILES | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3 | |
| InChIKey | VFMMPHCGEFXGIP-UHFFFAOYSA-N |
Alpha-Naphthoflavone (7,8-benzoflavone) is a synthetic flavonoid that acts as a potent inhibitor of aromatase (estrogen synthetase). By suppressing aromatase-mediated conversion of androgen precursor substrates into estrogens, alpha-naphthoflavone inhibits estrogen biosynthesis in steroidogenic cells. Downstream inhibition of estrogen signaling pathways reduces estrogen-receptor-dependent cell proliferation and alters hormone-regulated gene expression in tumor model systems. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
31 mg/mL
(113.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.