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alpha-MSH TFA

Synonyms:

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.

alpha-MSH TFA Chemical Structure

alpha-MSH TFA Chemical Structure

CAS: 171869-93-5

Purity & Quality Control

Batch: P120701 DMSO] 100 mg/mL] false] Water] 50 mg/mL] false] Ethanol] Insoluble] false Purity: 99.76%
99.76

alpha-MSH TFA Related Products

Biological Activity

Description

alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
Targets
hMC3R [1]
(in Hepa cells)		 hMC4 [1]
(in Hepa cells)
0.16 nM(EC50) 56 nM(EC50)
In vitro
In vitro

Alpha-MSH exerts an inhibitory effect on IL-8 production by macrophages, an influence that may occur via modulating NFκB activation. In human glioma cells, inflammatory reactions are modulated by α-MSH peptides, apparently by modulating NFκB activation through preventing IκB degradation.[2]
In Vivo
In vivo

Alpha-MSH inhibits both the induction and elicitation of contact sensitivity and can lead to hapten-specific tolerance. Although IL-10–deficient mice have reduced capacity to modulate both peripheral local and systemic inflammatory reactions, they are capable of reacting to exogenous α-MSH with reduced acute inflammatory reactions.[2]

Chemical Information & Solubility

Molecular Weight 1778.91 Formula

C77H109N21O19S.xC2HF3O2
CAS No. 171869-93-5 SDF --
Density 95.0~105.0%
Smiles CSCCC(NC(=O)C(CO)NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(CO)NC(C)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC2=C[NH]C=N2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC4=C[NH]C5=CC=CC=C45)C(=O)NCC(=O)NC(CCCCN)C(=O)N6CCCC6C(=O)NC(C(C)C)C(N)=O.OC(=O)C(F)(F)F
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (56.21 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 50 mg/mL

Ethanol : Insoluble


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In vivo
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