CAS No. 84380-01-8
Batch:
Purity:99.84
Chemical Structure
Check the
alpha-Arbutin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 84380-01-8 | |
|---|---|---|
| Molecular Formula |
C12H16O7 |
|
| Molecular Weight (MW) | 272.25 | |
| SMILES | C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O |
Alpha-Arbutin is a synthetic hydroquinone glucoside that acts as a potent tyrosinase inhibitor for skin lightening applications. By reversibly inhibiting tyrosinase activity, it blocks the rate-limiting conversion of L-tyrosine to L-DOPA within melanosomes, thereby attenuating melanogenesis. In cultured melanoma cells and human skin models, alpha-arbutin suppresses intracellular melanin synthesis without inducing cytotoxicity, serving as an effective depigmenting agent that modulates the melanin biosynthesis pathway. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(198.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.