CAS No. 1584128-91-5

Batch: Purity:96.66
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Alpelisib hydrochloride Chemical Structure
Chemical Structure
Check the Alpelisib hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide;hydrochloride
CAS Number 1584128-91-5
Molecular Formula

C19H22F3N5O2S.ClH
Molecular Weight (MW) 477.93
InChIKey HJNPFZMOUFLFRE-YDALLXLXSA-N

Ordering Information

Biological Activity

Alpelisib hydrochloride is a potent, isoform-specific PI3K inhibitor targeting p110α (IC50 =, p110β (IC50 =, p110δ (IC50 =, and p110γ (IC50 =. By blocking PI3Kα activity, it suppresses downstream AKT/mTOR pathway signaling, leading to reduced cellular proliferation and inhibition of tumor growth in PI3Kα-driven cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (200.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.