CAS No. 122852-69-1

Batch: Purity:99.86
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Alosetron Hydrochloride Chemical Structure
Chemical Structure
Check the Alosetron Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 122852-69-1
Molecular Formula

C17H18N4O.HCl
Molecular Weight (MW) 330.81
SMILES CC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl

Ordering Information

Biological Activity

Alosetron Hydrochloride is a potent and selective serotonin 5-HT3 receptor antagonist. By blocking 5-HT3 receptors on enteric neurons, it inhibits serotonin-mediated depolarization of visceral afferent nerves, thereby modulating gastrointestinal motility, secretions, and visceral pain signaling. These cellular effects reduce gut hypersensitivity and slow intestinal transit time, serving as a valuable tool for studying enteric neurotransmission.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 66 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.