CAS No. 30861-27-9

Batch: Purity:99.74
Check CoA
Aloesin Chemical Structure
Chemical Structure
Check the Aloesin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
CAS Number 30861-27-9
Molecular Formula

C19H22O9
Molecular Weight (MW) 394.37
SMILES CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(=O)C)C3C(C(C(C(O3)CO)O)O)O)O
InChIKey HKIKAXXIWJHWLY-ZIIYPAMZSA-N

Biological Activity

Aloesin is a natural chromone derivative isolated from Aloe vera that acts as a potent inhibitor of tyrosinase activity. By inhibiting tyrosinase, aloesin disrupts the melanogenesis pathway, suppressing melanin synthesis and reducing hyperpigmentation. Additionally, aloesin up-regulates cyclin E-dependent kinase activity in vitro, modulating cell cycle progression. These combined biological activities make aloesin a valuable compound for researching skin pigmentation mechanisms and cell cycle regulation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (197.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Choi S, et al. Clin Exp Dermatol. 2002;27(6):513-5.

Jump to

Note: Technical data last updated: Sep 1, 2026.