CAS No. 37510-29-5

Batch: Purity:98.02
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ALKBH5 inhibitor 1 (compound 3) Chemical Structure
Chemical Structure
Check the ALKBH5 inhibitor 1 (compound 3) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 37510-29-5
Molecular Formula

C10H10O4S
Molecular Weight (MW) 226.25

Biological Activity

ALKBH5 inhibitor 1 (compound 3) is a small-molecule inhibitor targeting the RNA m6A demethylase ALKBH5 with an IC50 value of 0.84 μM. By blocking ALKBH5-mediated m6A RNA demethylation, this compound alters epitranscriptomic RNA modifications and impairs downstream oncogenic signaling. Consequently, ALKBH5 inhibitor 1 (compound 3) exhibits potent antiproliferative activity, suppressing cancer cell growth in leukemia cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 45 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 45 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Selberg S, et al. ACS Omega. 2021;6(20):13310-13320.

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Note: Technical data last updated: Sep 1, 2026.