CAS No. 517-88-4
Batch:
Purity:99.71
Chemical Structure
Check the
Alkannin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione | |
|---|---|---|
| CAS Number | 517-88-4 | |
| Molecular Formula |
C16H16O5 |
|
| Molecular Weight (MW) | 289.37 | |
| SMILES | CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O | |
| InChIKey | NEZONWMXZKDMKF-JTQLQIEISA-N |
Alkannin is a naphthoquinone derivative and potent, selective inhibitor of tumor-specific pyruvate kinase M2 (PKM2) that does not inhibit PKM1 or pyruvate kinase-L. By targeting PKM2, it blocks cancer cell aerobic glycolysis, resulting in reduced glucose consumption and decreased lactate production. This inhibition of glycolytic flux impairs cellular energy generation, suppressing proliferation and inducing cell death in drug-sensitive and resistant tumor cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(345.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.