CAS No. 81403-80-7
Batch:
Purity:99.74
Chemical Structure
Check the
Alfuzosin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 81403-80-7 | |
|---|---|---|
| Molecular Formula |
C19H27N5O4 |
|
| Molecular Weight (MW) | 389.45 | |
| SMILES | CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC |
Biological Activity
Alfuzosin is a selective, quinazoline-derived competitive alpha1-adrenoceptor antagonist. By binding to and selectively inhibiting alpha1-adrenergic receptors, it blocks endogenous norepinephrine-mediated signaling pathways. This target inhibition relaxes prostatic and urethral smooth muscle tissue, attenuates sympathetic tone, and decreases lower urinary tract resistance while exhibiting minimal influence on systemic arterial blood pressure in preclinical models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(200.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.