CAS No. 1715-30-6
Batch:
Purity:100.00
Chemical Structure
Check the
Alexidine dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[N'-[6-[[amino-[[N'-(2-ethylhexyl)carbamimidoyl]amino]methylidene]amino]hexyl]carbamimidoyl]-2-(2-ethylhexyl)guanidine;dihydrochloride | |
|---|---|---|
| CAS Number | 1715-30-6 | |
| Molecular Formula |
C26H56N10.2ClH |
|
| Molecular Weight (MW) | 581.71 | |
| InChIKey | BRJJFBHTDVWTCJ-UHFFFAOYSA-N |
Alexidine dihydrochloride is a dibiguanide compound that acts as a selective inhibitor of protein tyrosine phosphatase localized to mitochondrion 1 (PTPMT1) with an IC50 of 1.08 μM in vitro. Targeting PTPMT1 alters mitochondrial protein phosphorylation and regulates mitochondrial metabolic pathways. In pancreatic beta-cells, this inhibition enhances glucose-stimulated insulin secretion, highlighting its potential utility in managing metabolic disorders such as type 2 diabetes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(171.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | 6 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.