CAS No. 1256589-74-8

Batch: Purity:99.93
Check CoA
Alectinib (CH5424802) hydrochloride Chemical Structure
Chemical Structure
Check the Alectinib (CH5424802) hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1256589-74-8
Molecular Formula

C30H34N4O2.HCl
Molecular Weight (MW) 519.08
SMILES CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl

Ordering Information

Biological Activity

Alectinib (CH5424802) hydrochloride is a potent and selective second-generation inhibitor of anaplastic lymphoma kinase (ALK). By blocking ALK kinase activity and auto-phosphorylation, it suppresses downstream STAT3 and AKT signaling pathways. This inhibition impairs cell proliferation and induces apoptosis in ALK-fusion-positive cancer cell lines, effectively overcoming resistance conferred by gatekeeper mutations in ALK-driven tumors.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 2 mg/mL (3.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.