CAS No. 842148-40-7
Batch:
Purity:96.61
Chemical Structure
Check the
AKT Kinase Inhibitor
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethylimidazo[4,5-c]pyridin-4-yl]prop-2-yn-1-ol | |
|---|---|---|
| CAS Number | 842148-40-7 | |
| Molecular Formula |
C16H19N7O3 |
|
| Molecular Weight (MW) | 357.37 | |
| InChIKey | LWLOLQIXHMFYND-UHFFFAOYSA-N |
Biological Activity
AKT Kinase Inhibitor is a small-molecule inhibitor of Akt that targets the AKT/mTOR signaling pathway. By suppressing Akt phosphorylation, it downregulates downstream survival cascades and attenuates cellular defense mechanisms against inflammatory damage. In lipopolysaccharide-treated prostate epithelial cells, inhibition of Akt attenuates cell viability, promotes apoptotic cell death, and increases pro-inflammatory cytokine levels, counteracting cytoprotective signaling responses. [1]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(19.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.