CAS No. 327092-81-9

Batch: Purity:99.52
Check CoA
AKR1C3-IN-1 Chemical Structure
Chemical Structure
Check the AKR1C3-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(3,4-dihydro-1H-isoquinolin-2-ylsulfonyl)benzoic acid
CAS Number 327092-81-9
Molecular Formula

C16H15NO4S
Molecular Weight (MW) 317.36
InChIKey ZGVIUMKHTXKKOX-UHFFFAOYSA-N

Biological Activity

AKR1C3-IN-1 is a potent inhibitor of aldo-keto reductase 1C3 (AKR1C3). By selectively inhibiting AKR1C3 enzyme activity, this compound disrupts the intratumoral biosynthesis and conversion of active androgenic and estrogenic steroids. Consequently, down-regulation of steroid hormone receptor signaling cascades leads to the inhibition of cell proliferation and the suppression of tumor growth phenotypes in hormone-dependent breast and prostate cancer research models.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 63 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.