CAS No. 1432515-73-5
Batch:
Purity:99.87
Chemical Structure
Check the
AKI603
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(4-methylpiperazin-1-yl)-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-(4-nitrophenyl)pyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 1432515-73-5 | |
| Molecular Formula |
C19H23N9O2 |
|
| Molecular Weight (MW) | 409.45 | |
| SMILES | CN1CCN(CC1)C2=NC(=NC(=C2)NC3=N[NH]C(=C3)C)NC4=CC=C(C=C4)[N;v5](=O)=O | |
| InChIKey | UNKOUVAYOLLXER-UHFFFAOYSA-N |
AKI603 is a small-molecule inhibitor of Aurora kinase A (AurA) developed to overcome imatinib resistance mediated by the BCR-ABL-TI mutation. In imatinib-resistant chronic myeloid leukemia cells, AurA inhibition by AKI603 suppresses cell proliferation and colony formation by inducing cell-cycle arrest and cellular senescence through elevated reactive oxygen species levels. Additionally, AKI603 attenuates tumor-initiating cell phenotypes in breast cancer models and downregulates stemness genes including β-catenin and c-Myc. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(200.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.