CAS No. 420831-40-9

Batch: Purity:99.97
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AK 7 Chemical Structure
Chemical Structure
Check the AK 7 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide
CAS Number 420831-40-9
Molecular Formula

C19H21BrN2O3S
Molecular Weight (MW) 437.35
SMILES C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br
InChIKey IYAYHZZWYNXHEQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

AK 7 is a brain-permeable, selective SIRT2 inhibitor with an IC50 of. By selectively inhibiting SIRT2 deacetylase activity, AK 7 modulates alpha-tubulin acetylation levels and regulates downstream cellular pathway signaling. This inhibition mitigates polyglutamine-mediated neurotoxicity and suppresses disease-associated phenotypic damage, promoting neuronal survival in experimental models of neurodegenerative conditions such as Huntington's disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (198.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.