CAS No. 2984505-88-4
Batch:
Purity:
Chemical Structure
Check the
AK-1690
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 2984505-88-4 | |
|---|---|---|
| Molecular Formula |
C51H56F2N5O11PS |
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| Molecular Weight (MW) | 1016.06 |
Biological Activity
AK-1690 is a selective PROTAC degrader targeting signal transducer and activator of transcription 6 (STAT6). By recruiting STAT6 to the cereblon E3 ubiquitin ligase complex, it induces ubiquitin-dependent proteasomal degradation of STAT6 in cells. Target removal impairs downstream IL-4 and IL-13 cytokine receptor signaling pathways, leading to reduced expression of STAT6-dependent genes involved in immune differentiation and allergic inflammatory responses. [1][2]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.