CAS No. 873305-35-2

Batch: Purity:99.95
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AIM-100 Chemical Structure
Chemical Structure
Check the AIM-100 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
CAS Number 873305-35-2
Molecular Formula

C23H21N3O2
Molecular Weight (MW) 371.43
SMILES C1CC(OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5
InChIKey XNFHHOXCDUAYSR-SFHVURJKSA-N

Biological Activity

AIM-100 is a potent small-molecule inhibitor of Ack1 (IC50 24 nM). By suppressing Ack1 kinase activity, AIM-100 blocks Ack1-mediated phosphorylation of histone H3 at tyrosine 88 and inhibits androgen receptor transcription. Consequently, attenuation of this signaling pathway suppresses prostate cancer cell proliferation and downregulates oncogenic gene expression in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (199.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 74 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Proc. Natl. Acad. Sci. U.S.A. 2010;107(52).

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Note: Technical data last updated: Sep 1, 2026.