CAS No. 122520-85-8
Batch:
Purity:99.51
Chemical Structure
Check the
AG99
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide | |
|---|---|---|
| CAS Number | 122520-85-8 | |
| Molecular Formula |
C10H8N2O3
|
|
| Molecular Weight (MW) | 204.18 | |
| SMILES | C1=CC(=C(C=C1C=C(C#N)C(=O)N)O)O | |
| InChIKey | USOXQZNJFMKTKJ-XVNBXDOJSA-N |
AG99, also known as Tyrphostin 46, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. By inhibiting EGFR kinase autophosphorylation, AG99 blocks downstream intracellular signaling pathways essential for cellular proliferation and survival. This targeted inhibition effectively suppresses tumor cell growth and attenuates mitogenic signaling in EGFR-dependent cellular models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(200.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.