CAS No. 122520-79-0
Batch:
Purity:99.91
Chemical Structure
Check the
Tyrphostin AG30 (AG30)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | |
|---|---|---|
| CAS Number | 122520-79-0 | |
| Molecular Formula |
C10H7NO4 |
|
| Molecular Weight (MW) | 205.17 | |
| SMILES | C1=CC(=C(C=C1C=C(C#N)C(=O)O)O)O | |
| InChIKey | CJMWBHLWSMKFSM-XVNBXDOJSA-N |
Tyrphostin AG30 (AG30) is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. By blocking c-ErbB kinase activity, AG30 disrupts downstream signaling networks, specifically preventing the activation of STAT5. Consequently, this targeted inhibition impairs c-ErbB-induced self-renewal in primary erythroblasts and suppresses signal transduction pathways that drive growth factor-dependent cellular proliferation and differentiation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(199.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.