CAS No. 149092-50-2
Batch:
Purity:99.41
Chemical Structure
Check the
AG 825
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-3-[3-(1,3-benzothiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxyphenyl]-2-cyanoprop-2-enamide | |
|---|---|---|
| CAS Number | 149092-50-2 | |
| Molecular Formula |
C19H15N3O3S2 |
|
| Molecular Weight (MW) | 397.47 | |
| InChIKey | KXDONFLNGBQLTN-WUXMJOGZSA-N |
AG 825 (Tyrphostin AG-825) is a potent and selective inhibitor of ErbB2 (IC50 = that also inhibits PDGFR autophosphorylation (IC50 =. By suppressing ErbB2 receptor tyrosine kinase activity, AG 825 interrupts downstream oncogenic signaling cascades, leading to the inhibition of cancer cell growth and survival. Consequently, this compound exhibits robust anti-cancer activity and significantly induces apoptosis in cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(198.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.