CAS No. 1446502-11-9
| IUPAC Name | 2-methyl-1-[[4-[6-(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]propan-2-ol | |
|---|---|---|
| CAS Number | 1446502-11-9 | |
| Molecular Formula |
C19H17F6N7O |
|
| Molecular Weight (MW) | 473.38 | |
| SMILES | CC(C)(CNC1=NC(=NC(=N1)C2=NC(=CC=C2)C(F)(F)F)NC3=CC(=NC=C3)C(F)(F)F)O | |
| InChIKey | DYLUUSLLRIQKOE-UHFFFAOYSA-N |
Enasidenib (AG-221) is a potent, reversible, and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2) enzymes, including IDH2-R140Q and IDH2-R172K variants. By selectively targeting mutant IDH2, AG-221 lowers intracellular levels of the oncometabolite 2-hydroxyglutarate (2-HG). This suppression releases histone and DNA hypermethylation blockades, promoting cellular differentiation and maturation in mutant IDH2 acute myeloid leukemia models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
94 mg/mL
(198.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(211.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
91 mg/mL
(192.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 91 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- AG-221 (Enasidenib) Mechanism of Action: IDH2 Inhibition in Myeloid Precursor Cell Research
- AG-221 (Enasidenib) Clinical Trials
- AG-221 (Enasidenib): Selectivity & Specificity
- AG-221 (Enasidenib) Working Concentration | Cell Culture | Treatment
- AG-221 (Enasidenib) Solubility in DMSO
- AG-221 (Enasidenib) Stock Solution
- AG-221 (Enasidenib) Storage
- AG-221 (Enasidenib) Stability
- AG-221 (Enasidenib) Combination Database
- AG-221 (Enasidenib) Molecular Weight
- AG-221 (Enasidenib) SMILES
- AG-221 (Enasidenib) Chemical Structure (2D and 3D)
- AG-221 (Enasidenib) IC50 for Cell-based and Cell-free Assays
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- AG-221 (Enasidenib) SDS｜MSDS