CAS No. 71897-07-9
Batch:
Purity:99.58
Chemical Structure
Check the
AG 1295
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6,7-dimethyl-2-phenylquinoxaline | |
|---|---|---|
| CAS Number | 71897-07-9 | |
| Molecular Formula |
C16H14N2 |
|
| Molecular Weight (MW) | 234.30 | |
| InChIKey | FQNCLVJEQCJWSU-UHFFFAOYSA-N |
Biological Activity
AG 1295 is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine kinase that potently inhibits PDGFR autophosphorylation in membrane assays. By blocking PDGFR-mediated signaling, it suppresses downstream cellular proliferation and DNA synthesis. Consequently, AG 1295 attenuates vascular smooth muscle cell growth and migration, leading to reduced neointimal formation following vascular balloon injury.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(34.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.