Molecular Weight: 625.87 g/mol

Afoxolaner Chemical Structure
Chemical Structure
Check the Afoxolaner product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (159.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Chemical Information

IUPAC Name 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]naphthalene-1-carboxamide
CAS Number 1093861-60-9
Molecular Formula

C26H17ClF9N3O3
Molecular Weight (MW) 625.87
SMILES FC(F)(F)CNC(=O)CNC(=O)C1=CC=C(C2=NOC(C2)(C3=CC(=CC(=C3)Cl)C(F)(F)F)C(F)(F)F)C4=C1C=CC=C4
InChIKey OXDDDHGGRFRLEE-UHFFFAOYSA-N

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Note: Technical data last updated: Sep 1, 2026.