CAS No. 1531634-31-7
Batch:
Purity:99.44
Chemical Structure
Check the
AF38469
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(6-methyl-2-pyridinyl)carbamoyl]-5-(trifluoromethyl)benzoic acid | |
|---|---|---|
| CAS Number | 1531634-31-7 | |
| Molecular Formula |
C15H11F3N2O3 |
|
| Molecular Weight (MW) | 324.26 | |
| SMILES | CC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2C(O)=O)C(F)(F)F | |
| InChIKey | JWCUSQCZMQIBMR-UHFFFAOYSA-N |
AF38469 is a selective, orally bioavailable inhibitor of sortilin with an IC50 value of 330 nM. By targeted inhibition of sortilin, AF38469 disrupts the binding and trafficking of key ligand partners such as neurotensin and proneurotrophins. This block in sortilin-mediated ligand internalization modulates downstream endosomal sorting pathways, altering lipid metabolism, lysosomal function, and neurotrophic factor signal transduction in preclinical models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.