CAS No. 1945941-72-9
Chemical Structure
Check the
ADT-1004
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [4-[(Z)-[5-fluoro-3-[2-(furan-2-ylmethylamino)-2-oxoethyl]-2-methylinden-1-ylidene]methyl]-2,6-dimethoxyphenyl] N-(1-methylpiperidin-4-yl)carbamate | |
|---|---|---|
| CAS Number | 1945941-72-9 | |
| Molecular Formula |
C33H36FN3O6 |
|
| Molecular Weight (MW) | 589.66 | |
| SMILES | O=C(NCC1=CC=CO1)CC2=C(C)/C(C3=CC=C(F)C=C32)=C/C4=CC(OC)=C(C(OC)=C4)OC(NC5CCN(CC5)C)=O | |
| InChIKey | QWYDVMJRUYFCPR-WGARJPEWSA-N |
ADT-1004 is an orally bioavailable prodrug of ADT-007 that acts as a first-in-class selective pan-RAS inhibitor. Targeting pan-RAS disrupts downstream oncogenic signaling cascades, including the MAPK/ERK and PI3K/AKT pathways. This targeted pathway inhibition suppresses tumor cell proliferation and survival, leading to potent antitumor efficacy in preclinical models of pancreatic ductal adenocarcinoma (PDAC). [1][2]
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Note: Technical data last updated: Sep 1, 2026.