CAS No. 1945941-09-2
Batch:
Purity:96.29
Chemical Structure
Check the
ADT-007
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(3Z)-6-fluoro-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-methylinden-1-yl]-N-(furan-2-ylmethyl)acetamide | |
|---|---|---|
| CAS Number | 1945941-09-2 | |
| Molecular Formula |
C26H24FNO5 |
|
| Molecular Weight (MW) | 449.47 | |
| InChIKey | CJBUOVAXMPVXFB-UKWGHVSLSA-N |
ADT-007 is a potent pan-RAS inhibitor that targets mutated and hyper-activated wild-type RAS isozymes. By binding nucleotide-free RAS, it blocks GTP loading and disrupts effector interactions, leading to the suppression of downstream MAPK and AKT signaling pathways. Consequently, ADT-007 inhibits cell proliferation and promotes mitotic arrest and selective apoptosis in RAS-driven cancer cells. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.