CAS No. 2055362-74-6

Batch: Purity:99.73
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ADH-503 (GB1275) Chemical Structure
Chemical Structure
Check the ADH-503 (GB1275) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[5-[(Z)-(3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate;2-hydroxyethyl(trimethyl)azanium
CAS Number 2055362-74-6
Molecular Formula

C22H15NO4S2.C5H14NO
Molecular Weight (MW) 525.66
SMILES C[N+](C)(C)CCO.C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)[O-])SC2=S
InChIKey GOWDQYRMBCOOJR-JHMJKTBASA-M

Biological Activity

ADH-503 (GB1275) is a small-molecule allosteric agonist of integrin CD11b. By binding to CD11b, ADH-503 enhances CD11b/CD18-mediated cell adhesion and alters myeloid cell trafficking and activation. This activation reprograms immunosuppressive tumor-associated macrophages and myeloid-derived suppressor cells within the microenvironment, reducing pro-inflammatory leukocyte recruitment and suppressing cell migration to regulate immune responses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (190.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.