CAS No. 18422-05-4

Batch: Purity:98
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Adenosine 5'-monophosphate monohydrate Chemical Structure
Chemical Structure
Check the Adenosine 5'-monophosphate monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 18422-05-4
Molecular Formula

C10H14N5O7P.H2O
Molecular Weight (MW) 365.24
SMILES C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N.O

Ordering Information

Biological Activity

Adenosine 5'-monophosphate monohydrate (5'-AMP) is an endogenous nucleotide that functions as an activator of AMP-activated protein kinase (AMPK). Upon binding to AMPK, 5'-AMP induces allosteric activation and promotes phosphorylation by upstream kinases, playing a key role in cellular energy homeostasis. Activation of AMPK downstream stimulates ATP-generating catabolic pathways, such as fatty acid oxidation, while inhibiting anabolic biosynthesis. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 9 mg/mL (24.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.