CAS No. 1384071-99-1
Batch:
Purity:99.85
Chemical Structure
Check the
AD80
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea | |
|---|---|---|
| CAS Number | 1384071-99-1 | |
| Molecular Formula |
C22H19F4N7O |
|
| Molecular Weight (MW) | 473.43 | |
| SMILES | CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)N | |
| InChIKey | CYORWDWRQMVGHN-UHFFFAOYSA-N |
AD80 is a potent multikinase inhibitor targeting RET, BRAF, S6K, and SRC while exhibiting minimal activity against mTOR. By simultaneously targeting RET and downstream effector pathways, AD80 suppresses oncogenic MAPK and mTOR/S6K signaling networks. This polypharmacological inhibition efficiently blocks tumor cell proliferation, survival, and migration in RET-driven cancer models while preventing compensatory pathway reactivation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 94 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.