CAS No. 2907782-78-7
Chemical Structure
Check the
AD1058
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-3-methyl-4-[7-methylsulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrrolo[2,3-d]pyrimidin-4-yl]morpholine | |
|---|---|---|
| CAS Number | 2907782-78-7 | |
| Molecular Formula | C19H20N6O3S | |
| Molecular Weight (MW) | 412.47 | |
| SMILES | O=S(N1C=CC2=C(N3[C@H](C)COCC3)N=C(C4=C5C(NC=C5)=NC=C4)N=C21)(C)=O | |
| InChIKey | IJEDYDGSAXSVPY-GFCCVEGCSA-N |
AD1058 is an orally bioavailable, brain-penetrant inhibitor targeting ataxia telangiectasia and Rad3-related (ATR) kinase. By blocking ATR-mediated DNA damage repair and signaling pathways, it effectively suppresses tumor cell proliferation, triggers cell cycle arrest, and promotes cell apoptosis. Consequently, this targeted pharmacological inhibition produces robust antitumor responses, supporting its utility in preclinical research on advanced malignancies and central nervous system metastases. [1][2]
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Note: Technical data last updated: Sep 1, 2026.