CAS No. 1497439-74-3
Batch:
Purity:98.67
Chemical Structure
Check the
AD-8007
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S)-2-amino-2-cyclopropyl-1-(3,3-diphenylpiperidin-1-yl)ethanone | |
|---|---|---|
| CAS Number | 1497439-74-3 | |
| Molecular Formula |
C22H26N2O |
|
| Molecular Weight (MW) | 334.46 | |
| InChIKey | RVDAHWSYHUHTAL-FQEVSTJZSA-N |
Biological Activity
AD-8007 is a selective and brain-penetrant inhibitor of acetyl-CoA synthetase 2 (ACSS2). By targeting ACSS2-mediated acetate metabolism, AD-8007 significantly suppresses intracellular acetyl-CoA production and downstream lipid storage in cancer cells. Consequently, this inhibition impairs cell colony formation and survival in vitro while reducing tumor burden and extending overall survival in in vivo models of breast cancer brain metastasis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.