Actinomycin D is a potent DNA-intercalating RNA polymerase inhibitor. It affects p53, MAPK, and NF-κB signaling pathways by blocking DNA-dependent RNA synthesis, thereby inhibiting cell proliferation and promoting apoptosis.
Actinomycin D (Dactinomycin) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Actinomycin D (Dactinomycin) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.