CAS No. 8048-52-0
Batch:
Purity:99.78
Chemical Structure
Check the
Acriflavine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride | |
|---|---|---|
| CAS Number | 8048-52-0 | |
| Molecular Formula |
C14H14N3.C13H11N3.Cl |
|
| Molecular Weight (MW) | 468.98 | |
| InChIKey | PEJLNXHANOHNSU-UHFFFAOYSA-N |
Acriflavine is a small-molecule inhibitor of hypoxia-inducible factor 1 (HIF-1) dimerization. By binding directly to the HIF-1α and HIF-2α subunits, it blocks interaction with HIF-1β, thereby disrupting the transcriptional activation of downstream HIF target genes. This downstream suppression of HIF-mediated angiogenic signaling results in potent inhibition of tumor cell growth, survival, and tumor vascularization.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 94 mg/mL |
| Ethanol | 2 mg/mL |
| DMSO |
94 mg/mL
(200.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 94 mg/mL |
| Ethanol | 7 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.