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Acivicin hydrochloride GGT inhibitor

Cat.No.E5859

Acivicin hydrochloride (AT-125 hydrochloride) is the hydrochloride salt of Acivicin, a natural antibiotic produced by Streptomyces sviceus. It is a potent inhibitor of γ-glutamyl transpeptidase (GGT), an enzyme that initiates glutathione catabolism to cysteine. Acivicin also exhibits anti-cancer and anti-parasitic properties.
Acivicin hydrochloride GGT inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 215.03

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Chemical Information, Storage & Stability

Molecular Weight 215.03 Formula

C5H8Cl2N2O3

 Storage (From the date of receipt)
CAS No. 161922-40-3 Download SDF Storage of Stock Solutions

Synonyms AT-125 hydrochloride; U-42126 hydrochloride Smiles [H]Cl.ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1

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Mechanism of Action

In vivo

Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%.
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