CAS No. 968-81-0
Batch:
Purity:99.13
Chemical Structure
Check the
Acetohexamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea | |
|---|---|---|
| CAS Number | 968-81-0 | |
| Molecular Formula |
C15H20N2O4S |
|
| Molecular Weight (MW) | 324.40 | |
| SMILES | CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2 | |
| InChIKey | VGZSUPCWNCWDAN-UHFFFAOYSA-N |
Acetohexamide is a first-generation oral sulfonylurea that acts as a hypoglycemic agent by targeting ATP-sensitive potassium (K-ATP) channels in pancreatic beta cells. By binding to sulfonylurea receptors, it induces K-ATP channel closure, leading to membrane depolarization and calcium influx. This cascade triggers exocytosis and release of insulin, thereby enhancing glucose uptake and promoting glycemic control. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
21 mg/mL
(64.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
11 mg/mL
(33.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.