CAS No. 831234-13-0
Batch:
Purity:99.94
Chemical Structure
Check the
AC1903
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine | |
|---|---|---|
| CAS Number | 831234-13-0 | |
| Molecular Formula |
C19H17N3O |
|
| Molecular Weight (MW) | 303.36 | |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2NCC4=CC=CO4 | |
| InChIKey | OECUWHDVQIITIS-UHFFFAOYSA-N |
AC1903 is a selective transient receptor potential canonical channel 5 (TRPC5) inhibitor. By specifically blocking TRPC5 ion channel activity, AC1903 suppresses calcium influx and downstream Rac1 signaling pathways in renal podocytes. This targeted channel inhibition protects podocyte structural integrity, prevents severe cellular injury, and suppresses progressive proteinuria in animal models of focal segmental glomerulosclerosis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(197.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.