CAS No. 169332-60-9
Batch:
Purity:98.86
Chemical Structure
Check the
Ac-DEVD-CHO
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid | |
|---|---|---|
| CAS Number | 169332-60-9 | |
| Molecular Formula |
C20H30N4O11 |
|
| Molecular Weight (MW) | 502.47 | |
| SMILES | CC(C)C(C(=O)NC(CC(=O)O)C=O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C | |
| InChIKey | UMBVAPCONCILTL-MRHIQRDNSA-N |
Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases, demonstrating high affinity for caspase-3 (Ki = and caspase-7 (Ki =, with weak activity against caspase-2. By reversibly inhibiting these key executioner caspases, Ac-DEVD-CHO blocks pro-apoptotic substrate cleavage and attenuates the downstream apoptotic cascade, effectively preventing programmed cell death in various cellular models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.