CAS No. 775294-71-8
Batch:
Purity:99.047
Chemical Structure
Check the
AC-73
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[1-hydroxy-2-[(4-phenylphenyl)methylamino]ethyl]phenol | |
|---|---|---|
| CAS Number | 775294-71-8 | |
| Molecular Formula |
C21H21NO2 |
|
| Molecular Weight (MW) | 319.40 | |
| InChIKey | UECKKYNEEBRMIL-UHFFFAOYSA-N |
AC-73 is an orally active, specific small-molecule inhibitor of transmembrane protein CD147. It disrupts CD147 dimerization, thereby suppressing the downstream CD147/ERK1/2/STAT3/MMP-2 signaling pathway. Inhibition of this signaling cascade suppresses cell mobility and metastatic invasion in hepatocellular carcinoma models. Furthermore, AC-73 exerts anti-proliferative activity in acute myeloid leukemia cells by inducing autophagy and enhancing chemotherapeutic sensitivity. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.